Association of incident obstructive sleep apnoea with outcomes in a large cohort of US veterans.

ABSTRACT:

Rationale

There is a paucity of large cohort studies examining the association of obstructive sleep apnoea (OSA) with clinical outcomes including all-cause mortality, coronary heart disease (CHD), strokes and chronic kidney disease (CKD).

Objectives

We hypothesised that a diagnosis of incident OSA is associated with higher risks of these adverse clinical outcomes.

Methods, measurements

In a nationally representative cohort of over 3 million (n=3 079 514) US veterans (93% male) with baseline estimated glomerular filtration rate (eGFR)≥60 mL/min/1.73 m(2), we examined the association between the diagnosis of incident OSA, treated and untreated with CPAP, and: (1) all-cause mortality, (2) incident CHD, (3) incident strokes, (4)incident CKD defined as eGFR<60 mL/min/1.73 

SUBMITTER: Molnar MZ 

PROVIDER: S-EPMC4575815 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature