Abnormal white matter connections between medial frontal regions predict symptoms in patients with first episode schizophrenia.

ABSTRACT:

Introduction

The medial orbitofrontal cortex (mOFC) and rostral part of anterior cingulate cortex (rACC) have been suggested to be involved in the neural network of salience and emotional processing, and associated with specific clinical symptoms in schizophrenia. Considering the schizophrenia dysconnectivity hypothesis, the connectivity abnormalities between mOFC and rACC might be associated with clinical characteristics in first episode schizophrenia patients (FESZ).

Methods

After parcellating mOFC into the anterior and posterior part, diffusion properties of the mOFC-rACC white matter connections for 21 patients with FESZ and 21 healthy controls (HCs) were examined using stochastic tractography, one of the most effective Diffusion Tensor Imaging (DTI) methods for examinin

SUBMITTER: Ohtani T 

PROVIDER: S-EPMC4575843 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature