Use of proton pump inhibitors is associated with fractures in young adults: a population-based study.

ABSTRACT:

Unlabelled

Proton pump inhibitors (PPIs) are associated with risk for fracture in osteoporotic adults. In this population-based study, we found a significant association between PPIs and fracture in young adults, with evidence of a dose-response effect. Young adults who use PPIs should be cautioned regarding risk for fracture.

Introduction

Proton pump inhibitors (PPIs) are associated with fracture in adults with osteoporosis. Because PPI therapy may interfere with bone accrual and attainment of peak bone mineral density, we studied the association between use of PPIs and fracture in children and young adults.

Methods

We conducted a population-based, case-control study nested within records from general medical practices from 1994 to 2013. Participants were 4-29 years

SUBMITTER: Freedberg DE 

PROVIDER: S-EPMC4575851 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature