Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse.

ABSTRACT:

Background & aims

Regeneration of the hepatic mass is crucial to liver repair. Proliferation of hepatic parenchyma is intimately dependent on angiogenesis and resident macrophage-derived cytokines. However the role of circulating monocyte interactions in vascular and hepatic regeneration is not well-defined. We investigated the role of these interactions in regeneration in the presence and absence of intact monocyte adhesion.

Methods

Partial hepatectomy was performed in wild-type mice and those lacking the monocyte adhesion molecule CD11b. Vascular architecture, angiogenesis and macrophage location were analyzed in the whole livers using simultaneous angiography and macrophage staining with fluorescent multiphoton microscopy. Monocyte adhesion molecule expression and sprouti

SUBMITTER: Melgar-Lesmes P 

PROVIDER: S-EPMC4575901 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature