Current understanding of mdig/MINA in human cancers.

ABSTRACT:

Unlabelled

Mineral dust-induced gene, mdig has recently been identified and is known to be overexpressed in a majority of human cancers and holds predictive power in the poor prognosis of the disease. Mdig is an environmentally expressed gene that is involved in cell proliferation, neoplastic transformation and immune regulation. With the advancement in deciphering the prognostic role of mdig in human cancers, our understanding on how mdig renders a normal cell to undergo malignant transformation is still very limited. This article reviews the current knowledge of the mdig gene in context to human neoplasias and its relation to the clinico-pathologic factors predicting the outcome of the disease in patients. It also emphasizes on the promising role of mdig that can serve as a poten

SUBMITTER: Thakur C 

PROVIDER: S-EPMC4575916 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature