Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP.

ABSTRACT: The glucocorticoid receptor (GR) is a steroid-hormone-activated transcription factor that modulates gene expression. Transcriptional regulation by the GR requires dynamic receptor binding to specific target sites located across the genome. This binding remodels the chromatin structure to allow interaction with other transcription factors. Thus, chromatin remodeling is an essential component of GR-mediated transcriptional regulation, and understanding the interactions between these molecules at the structural level provides insights into the mechanisms of how GR and chromatin remodeling cooperate to regulate gene expression. This study suggests models for the assembly of the SWI/SNF-A (SWItch/Sucrose-NonFermentable) complex and its interaction with the GR. We used the PRISM algorithm (PRote

SUBMITTER: Muratcioglu S 

PROVIDER: S-EPMC4576152 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature