Structural Perspectives on the Evolutionary Expansion of Unique Protein-Protein Binding Sites.

ABSTRACT: Structures of protein complexes provide atomistic insights into protein interactions. Human proteins represent a quarter of all structures in the Protein Data Bank; however, available protein complexes cover less than 10% of the human proteome. Although it is theoretically possible to infer interactions in human proteins based on structures of homologous protein complexes, it is still unclear to what extent protein interactions and binding sites are conserved, and whether protein complexes from remotely related species can be used to infer interactions and binding sites. We considered biological units of protein complexes and clustered protein-protein binding sites into similarity groups based on their structure and sequence, which allowed us to identify unique binding sites. We showed tha

SUBMITTER: Goncearenco A 

PROVIDER: S-EPMC4576154 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature