Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons.

ABSTRACT: Dendritic integration of synaptic inputs mediates rapid neural computation as well as longer-lasting plasticity. Several channel types can mediate dendritically initiated spikes (dSpikes), which may impact information processing and storage across multiple timescales; however, the roles of different channels in the rapid vs long-term effects of dSpikes are unknown. We show here that dSpikes mediated by Nav channels (blocked by a low concentration of TTX) are required for long-term potentiation (LTP) in the distal apical dendrites of hippocampal pyramidal neurons. Furthermore, imaging, simulations, and buffering experiments all support a model whereby fast Nav channel-mediated dSpikes (Na-dSpikes) contribute to LTP induction by promoting large, transient, localized increases in intracellula

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4576155 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature