The Role of Conformational Dynamics and Allostery in the Disease Development of Human Ferritin.

ABSTRACT: Determining the three-dimensional structure of myoglobin, the first solved structure of a protein, fundamentally changed the way protein function was understood. Even more revolutionary was the information that came afterward: protein dynamics play a critical role in biological functions. Therefore, understanding conformational dynamics is crucial to obtaining a more complete picture of protein evolution. We recently analyzed the evolution of different protein families including green fluorescent proteins (GFPs), β-lactamase inhibitors, and nuclear receptors, and we observed that the alteration of conformational dynamics through allosteric regulation leads to functional changes. Moreover, proteome-wide conformational dynamics analysis of more than 100 human proteins showed that mutations o

SUBMITTER: Kumar A 

PROVIDER: S-EPMC4576160 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature