Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin.

ABSTRACT: The high prevalence of hepatitis C virus (HCV) infection in the human population has triggered intensive research efforts that have led to the development of curative antiviral therapy. Moreover, HCV has become a role model to study fundamental principles that govern the replication cycle of a positive strand RNA virus. In fact, for most HCV proteins high-resolution X-ray and NMR (Nuclear Magnetic Resonance)-based structures have been established and profound insights into their biochemical and biological properties have been gained. One example is p7, a small hydrophobic protein that is dispensable for RNA replication, but crucial for the production and release of infectious HCV particles from infected cells. Owing to its ability to insert into membranes and assemble into homo-oligomeric

SUBMITTER: Madan V 

PROVIDER: S-EPMC4576187 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature