Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?

ABSTRACT: We examine the contrast between mechanisms for allosteric signaling that involve structural change, and those that do not, from the perspective of allosteric pathways. In particular we treat in detail the case of fluctuation-allostery by which amplitude modulation of the thermal fluctuations of the elastic normal modes conveys the allosteric signal, and address the question of what an allosteric pathway means in this case. We find that a perturbation theory of thermal elastic solids and nonperturbative approach (by super-coarse-graining elasticity into internal bending modes) have opposite signatures in their structure of correlated pathways. We illustrate the effect from analysis of previous results from GlxR of Corynebacterium glutamicum, an example of the CRP/FNR transcription family of

SUBMITTER: McLeish TC 

PROVIDER: S-EPMC4576321 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature