Association of the CTLA4 gene CT60/rs3087243 single-nucleotide polymorphisms with Graves' disease.

ABSTRACT: It has been widely reported that the CT60 single-nucleotide polymorphism (SNP), which is in the 3'-untranslated region of the cytotoxic T lymphocyte associated 4 (CTLA4) gene, is strongly correlated with certain immune-mediated diseases. The present case-control study aimed to investigate the genetic association between the CT60 SNP within the CTLA4 gene and Graves' disease (GD). A total of 288 patients with GD and 290 control subjects were recruited for the study. The CT60 SNP of the CTLA4 gene was detected by direct DNA sequencing. The results indicated that the frequencies of the GG genotype and G allele in the case group were evidently higher than that in the control group (P=4×10^-6 and P=2.9×10^-5, respectively). Furthermore, the G/G genotype

SUBMITTER: Fang W 

PROVIDER: S-EPMC4576490 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature