DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.

ABSTRACT:

Motivation

To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels. However, the ever increasing size and ethnic diversity of both reference panels and cohorts makes genotype imputation computationally challenging for moderately sized computer clusters. Moreover, genotype imputation requires subject-level genetic data, which unlike summary statistics provided by virtually all studies, is not publicly available. While there are much less demanding methods which avoid the genotype imputation step by directly imputing SNP statistics, e.g. Directly Imputing summary STatistics (DIST) proposed by our group, their implici

SUBMITTER: Lee D 

PROVIDER: S-EPMC4576696 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature