Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2.

ABSTRACT: We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

SUBMITTER: Porter JR 

PROVIDER: S-EPMC4576826 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature