Prospective study of plasma D-dimer and incident venous thromboembolism: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Introduction

Plasma D-dimer is a useful clinical test for acute venous thromboembolism (VTE), and concentrations remain higher in VTE patients after treatment than in controls. Yet, evidence is limited on whether higher basal D-dimer concentrations in the general population are associated with greater risk of first VTE.

Objective

To assess the prospective association between D-dimer and incident VTE over a long follow-up.

Methods

We measured plasma D-dimer in 12,097 participants, initially free of VTE, in the Atherosclerosis Risk in Communities Study. Over a median follow-up of 17years, we identified 521 VTEs. We calculated hazard ratios of VTE using proportional hazards regression.

Results

The age, race, and sex adjusted hazard ratios of VTE across quintiles o

SUBMITTER: Folsom AR 

PROVIDER: S-EPMC4577468 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature