Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.

ABSTRACT: Regulatory T (T reg) cells are central mediators of immune suppression. As such, T reg cells are characterized by a distinct pattern of gene expression, which includes up-regulation of immunosuppressive genes and silencing of inflammatory cytokine genes. Although an increasing number of transcription factors that regulate T reg cells have been identified, the mechanisms by which the T reg cell-specific transcriptional program is maintained and executed remain largely unknown. The Nr4a family of nuclear orphan receptors, which we recently identified as essential for the development of T reg cells, is highly expressed in mature T reg cells as well, suggesting that Nr4a factors play important roles even beyond T reg cell development. Here, we showed that deletion of Nr4a genes specifically in

SUBMITTER: Sekiya T 

PROVIDER: S-EPMC4577835 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature