Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B.

ABSTRACT: We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 essential for HHV-6B entry.

SUBMITTER: Tang H 

PROVIDER: S-EPMC4577881 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature