Transcriptional Profiling of the Immune Response to Marburg Virus Infection.

ABSTRACT:

Unlabelled

Marburg virus is a genetically simple RNA virus that causes a severe hemorrhagic fever in humans and nonhuman primates. The mechanism of pathogenesis of the infection is not well understood, but it is well accepted that pathogenesis is appreciably driven by a hyperactive immune response. To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic analysis of immune cells circulating in the blood following aerosol exposure of rhesus macaques to a lethal dose of Marburg virus. Using two-color microarrays, we analyzed the transcriptomes of peripheral blood mononuclear cells that were collected throughout the course of infection from 1 to 9 days postexposure, representing the full course of the infection. The response followed a 3-stag

SUBMITTER: Connor JH 

PROVIDER: S-EPMC4577901 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature