Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.

ABSTRACT: The modulation of protein-protein interactions (PPIs) by means of creating or stabilizing secondary structure conformations is a rapidly growing area of research. Recent success in the inhibition of difficult PPIs by secondary structure mimetics also points to potential limitations, because often, specific cases require tertiary structure mimetics. To streamline protein structure-based inhibitor design, we have previously described the examination of protein complexes in the Protein Data Bank where α-helices or β-strands form critical contacts. Here, we examined coiled coils and helix bundles that mediate complex formation to create a platform for the discovery of potential tertiary structure mimetics. Though there has been extensive analysis of coiled coil motifs, the interactions between

SUBMITTER: Watkins AM 

PROVIDER: S-EPMC4577960 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature