Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population.

ABSTRACT:

Background/aims

A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population.

Methods

Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction.

Results

Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also a

SUBMITTER: Do SK 

PROVIDER: S-EPMC4578038 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature