The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis.

ABSTRACT: Multiple sclerosis is one of the most common causes of chronic neurological disability beginning in early to middle adult life. Multiple sclerosis is idiopathic in nature, yet increasing correlative evidence supports a strong association between one's genetic predisposition, the environment and the immune system. Symptoms of multiple sclerosis have primarily been shown to result from a disruption in the integrity of myelinated tracts within the white matter of the central nervous system. However, recent research has also highlighted the hitherto underappreciated involvement of gray matter in multiple sclerosis disease pathophysiology, which may be especially relevant when considering the accumulation of irreversible damage and progressive disability. This review aims at providing a compreh

SUBMITTER: Mallucci G 

PROVIDER: S-EPMC4578232 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature