Omic personality: implications of stable transcript and methylation profiles for personalized medicine.

ABSTRACT:

Background

Personalized medicine is predicated on the notion that individual biochemical and genomic profiles are relatively constant in times of good health and to some extent predictive of disease or therapeutic response. We report a pilot study quantifying gene expression and methylation profile consistency over time, addressing the reasons for individual uniqueness, and its relation to N = 1 phenotypes.

Methods

Whole blood samples from four African American women, four Caucasian women, and four Caucasian men drawn from the Atlanta Center for Health Discovery and Well Being study at three successive 6-month intervals were profiled by RNA-Seq, miRNA-Seq, and Illumina Methylation 450 K arrays. Standard regression approaches were used to evaluate the proportion of variance f

SUBMITTER: Tabassum R 

PROVIDER: S-EPMC4578259 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature