Bacterial clearance reverses a skewed T-cell repertoire induced by Salmonella infection.

ABSTRACT: Salmonella typhimurium invades the spleen, liver, and peripheral lymph nodes and has recently been detected in the bone marrow and thymus, resulting in a reduced thymic size and a decline in the total number of thymic cells. A specific deletion of the double-positive cell subset has been characterized, yet the export of mature T cells to the periphery remains normal. We analyzed Salmonella pathogenesis regarding thymic structure and the T-cell maturation process. We demonstrate that, despite alterations in the thymic structure, T-cell development is maintained during Salmonella infection, allowing the selection of single-positive T-cell clones expressing particular T-cell receptor beta chains (TCR-Vβ). Moreover, the treatment of infected mice with an antibiotic restored the normal thymic a

SUBMITTER: Leyva-Rangel JP 

PROVIDER: S-EPMC4578521 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature