Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.

ABSTRACT:

Background

Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into disease pathophysiology by correlating genomic landscape with clinical behavior, thereby identifying distinct HGG molecular subgroups associated with improved prognosis, we performed a comprehensive genomic analysis.

Methods

We analyzed and compared 720 exome-sequenced gliomas (136 from Yale, 584 from The Cancer Genome Atlas) based on their genomic, histological, and clinical features.

Results

We identified a subgroup of HGGs (6 total, 4 adults and 2 children) that harbored

SUBMITTER: Erson-Omay EZ 

PROVIDER: S-EPMC4578578 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature