Melanoma brain metastasis is independent of lactate dehydrogenase A expression.

ABSTRACT:

Background

The key metabolic enzyme lactate dehydrogenase A (LDHA) is overexpressed in many cancers, and several preclinical studies have shown encouraging results of targeted inhibition. However, the mechanistic importance of LDHA in melanoma is largely unknown and hitherto unexplored in brain metastasis.

Methods

We investigated the spatial, temporal, and functional features of LDHA expression in melanoma brain metastasis across multiple in vitro assays, in a robust and predictive animal model employing MRI and PET imaging, and in a unique cohort of 80 operated patients. We further assessed the genomic and proteomic landscapes of LDHA in different cancers, particularly melanomas.

Results

LDHA expression was especially strong in early and small brain metastases in viv

SUBMITTER: Sundstrom T 

PROVIDER: S-EPMC4578581 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature