Early investigational therapeutics for gastrointestinal motility disorders: from animal studies to Phase II trials.

ABSTRACT:

Introduction

The most common gastrointestinal disorders that include evidence of dysmotility include: gastroparesis, the lower functional gastrointestinal disorders associated with altered bowel function (such as chronic [functional] diarrhea, chronic idiopathic constipation) and opioid-induced constipation. These conditions, which are grouped as gastrointestinal motility and functional disorders, are characterized by abnormal motor, sensory or secretory functions that alter bowel function and result in a significant disease burden, since currently available treatments do not completely alleviate symptoms. New drugs are being developed for these disorders, targeting mechanisms involved in the pathophysiology of these diseases, specifically, motor function, intestinal secretion and

SUBMITTER: Valentin N 

PROVIDER: S-EPMC4578705 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature