Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial.

ABSTRACT:

Importance

Osteoporosis and cardiovascular disease may share common biological pathways, with inflammation playing a role in the development of both. Although observational studies have suggested that statin use is associated with a lower risk of fractures, randomized trial data addressing this issue are scant.

Objective

To determine whether statin therapy reduces the risk of fracture and, in a secondary analysis, whether baseline levels of the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) are associated with the risk of fracture.

Design, setting, and participants

The JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial was an international, randomized, double-blind, placebo-controlled

SUBMITTER: Pena JM 

PROVIDER: S-EPMC4578729 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature