Comparative genomics of Steinernema reveals deeply conserved gene regulatory networks.

ABSTRACT:

Background

Parasitism is a major ecological niche for a variety of nematodes. Multiple nematode lineages have specialized as pathogens, including deadly parasites of insects that are used in biological control. We have sequenced and analyzed the draft genomes and transcriptomes of the entomopathogenic nematode Steinernema carpocapsae and four congeners (S. scapterisci, S. monticolum, S. feltiae, and S. glaseri).

Results

We used these genomes to establish phylogenetic relationships, explore gene conservation across species, and identify genes uniquely expanded in insect parasites. Protein domain analysis in Steinernema revealed a striking expansion of numerous putative parasitism genes, including certain protease and protease inhibitor families, as well as fatty acid- and ret

SUBMITTER: Dillman AR 

PROVIDER: S-EPMC4578762 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature