Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study.

ABSTRACT:

Background

Development of adult respiratory disease is influenced by events in childhood. The impact of childhood pneumonia on chronic obstructive pulmonary disease (COPD) is not well defined. We hypothesize that childhood pneumonia is a risk factor for reduced lung function and COPD in adult smokers.

Methods

COPD cases and control smokers between 45-80 years old from the United States COPDGene Study were included. Childhood pneumonia was defined by self-report of pneumonia at <16 years. Subjects with lung disease other than COPD or asthma were excluded. Smokers with and without childhood pneumonia were compared on measures of respiratory disease, lung function, and quantitative analysis of chest CT scans.

Results

Of 10,192 adult smokers, 854 (8.4%) reported pneumonia

SUBMITTER: Hayden LP 

PROVIDER: S-EPMC4578796 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature