Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis.

ABSTRACT:

Rationale

Therapeutically targeting macrophage reverse cholesterol transport is a promising approach to treat atherosclerosis. Macrophage energy metabolism can significantly influence macrophage phenotype, but how this is controlled in foam cells is not known. Bioinformatic pathway analysis predicts that miR-33 represses a cluster of genes controlling cellular energy metabolism that may be important in macrophage cholesterol efflux.

Objective

We hypothesized that cellular energy status can influence cholesterol efflux from macrophages, and that miR-33 reduces cholesterol efflux via repression of mitochondrial energy metabolism pathways.

Methods and results

In this study, we demonstrated that macrophage cholesterol efflux is regulated by mitochondrial ATP production, a

SUBMITTER: Karunakaran D 

PROVIDER: S-EPMC4578799 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature