Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis.

ABSTRACT: The rising prevalence of obesity in the last few decades has been accompanied by an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD encompasses a spectrum of liver pathology from isolated hepatic steatosis to steatohepatitis and advanced fibrosis. Dietary habits characterized by consumption of high-caloric, lipid-rich diets play a major role in the development of NAFLD. Recent studies have uncovered the importance of certain components of the diet. In this review, we will focus on the growing evidence for a central role of n-6 polyunsaturated fatty acids. We will discuss novel findings linking oxidative stress and increased production of reactive oxygen species in the liver to oxidation of n-6 polyunsaturated fatty acids and production of specific lipid oxidation metabolites. I

SUBMITTER: Santoro N 

PROVIDER: S-EPMC4578804 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature