Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort.

ABSTRACT:

Background

Few studies have prospectively evaluated the progression of chronic kidney disease (CKD) in children and adolescents, as well as factors associated with progression.

Study design

Prospective multicenter observational cohort study.

Setting & participants

496 children and adolescents with CKD enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

Predictors

Proteinuria, hypoalbuminemia, blood pressure, dyslipidemia, and anemia.

Outcomes

Parametric failure-time models were used to characterize adjusted associations between baseline levels and changes in predictors and time to a composite event of renal replacement therapy or 50% decline in glomerular filtration rate (GFR).

Results

398 patients had nonglomerular disease and 98 had

SUBMITTER: Warady BA 

PROVIDER: S-EPMC4578873 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature