Low levels of C-peptide have clinical significance for established Type 1 diabetes.

ABSTRACT:

Aim

To determine whether the low C-peptide levels (< 50 pmol/l) produced by the pancreas for decades after onset of Type 1 diabetes have clinical significance.

Methods

We evaluated fasting C-peptide levels, duration of disease and age of onset in a large cross-sectional series (n = 1272) of people with Type 1 diabetes. We then expanded the scope of the study to include the relationship between C-peptide and HbA1c control (n = 1273), as well as diabetic complications (n = 324) and presence of hypoglycaemia (n = 323). The full range of C-peptide levels was also compared with 1,5-Anhydroglucitol, a glucose responsive marker.

Results

C-peptide levels declined for decades after diagnosis, and the rate of decline was significantly related to age of onset (P < 0.0001), after

SUBMITTER: Kuhtreiber WM 

PROVIDER: S-EPMC4578991 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature