Metformin effects on biochemical recurrence and metabolic signaling in the prostate.

ABSTRACT:

Background

Metformin has received considerable attention as a potential anti-cancer agent. Animal and in-vitro prostate cancer (PCa) models have demonstrated decreased tumor growth with metformin, however the precise mechanisms are unknown. We examine the effects of metformin on PCa biochemical recurrence (BCR) in a large clinical database followed by evaluating metabolic signaling changes in a cohort of men undergoing prostate needle biopsy (PNB).

Methods

Men treated for localized PCa were identified in a comprehensive clinical database between 2001 and 2010. Cox regression was performed to determine association with BCR relative to metformin use. We next identified a separate case-control cohort of men undergoing prostate needle biopsy (PNB) stratified by metformin use. Di

SUBMITTER: Winters B 

PROVIDER: S-EPMC4578998 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature