Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.

ABSTRACT: The genetic disorder cystic fibrosis is a life-limiting condition affecting ∼70,000 people worldwide. Targeted, early, treatment of the dominant infecting species, Pseudomonas aeruginosa, has improved patient outcomes; however, there is concern that other species are now stepping in to take its place. In addition, the necessarily long-term antibiotic therapy received by these patients may be providing a suitable environment for the emergence of antibiotic resistance. To investigate these issues, we employed whole-genome sequencing of 28 non-Pseudomonas bacterial strains isolated from three paediatric patients. We did not find any trend of increasing antibiotic resistance (either by mutation or lateral gene transfer) in these isolates in comparison with other examples of the same species. I

SUBMITTER: Ormerod KL 

PROVIDER: S-EPMC4579023 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature