Unknown

Dataset Information

0

Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NF?B2/p100.

ABSTRACT: We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NF?B2)/p100 was overexpressed after galactomannan challenge. Knocking down NF?B2/p100 using small interfering RNA (siRNA) indicated that NF?B2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required.

SUBMITTER: Toledano V 

PROVIDER: S-EPMC4579314 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in  ...[more]

Similar Datasets

Unknown SCF-mediated degradation of p100 (NF-?B2): mechanisms and relevance in multiple myeloma.
| S-EPMC3871187 | biostudies-literature
Unknown Immune Differentiation Regulator p100 Tunes NF-κB Responses to TNF.
| S-EPMC6514058 | biostudies-literature
Unknown The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-?B2 activation.
| S-EPMC5833803 | biostudies-literature
Genomics Immune differentiation regulator p100 tunes NF-kB responses to TNF
2020-08-22 | GSE119961 | GEO
Unknown p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.
| S-EPMC3994464 | biostudies-literature
Unknown TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy.
| S-EPMC6947505 | biostudies-literature
Unknown SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing.
| S-EPMC2529344 | biostudies-literature
Unknown Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.
| S-EPMC8480669 | biostudies-literature
Unknown Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation.
| S-EPMC3879294 | biostudies-literature
Unknown Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-?B Signaling Cascades.
| S-EPMC7408066 | biostudies-literature