Spatiotemporal Targeting of a Dual-Ligand Nanoparticle to Cancer Metastasis.

ABSTRACT: Various targeting strategies and ligands have been employed to direct nanoparticles to tumors that upregulate specific cell-surface molecules. However, tumors display a dynamic, heterogeneous microenvironment, which undergoes spatiotemporal changes including the expression of targetable cell-surface biomarkers. Here, we investigated a dual-ligand nanoparticle to effectively target two receptors overexpressed in aggressive tumors. By using two different chemical specificities, the dual-ligand strategy considered the spatiotemporal alterations in the expression patterns of the receptors in cancer sites. As a case study, we used two mouse models of metastasis of triple-negative breast cancer using the MDA-MB-231 and 4T1 cells. The dual-ligand system utilized two peptides targeting P-selectin

SUBMITTER: Doolittle E 

PROVIDER: S-EPMC4579532 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature