Eimeria bovis infection modulates endothelial host cell cholesterol metabolism for successful replication.

ABSTRACT: During first merogony Eimeria bovis forms large macromeronts in endothelial host cells containing >120 000 merozoites I. During multiplication, large amounts of cholesterol are indispensable for the enormous offspring membrane production. Cholesterol auxotrophy was proven for other apicomplexan parasites. Consequently they scavenge cholesterol from their host cell apparently in a parasite-specific manner. We here analyzed the influence of E. bovis infection on endothelial host cell cholesterol metabolism and found considerable differences to other coccidian parasites. Overall, free cholesterol significantly accumulated in E. bovis infected host cells. Furthermore, a striking increase of lipid droplet formation was observed within immature macromeronts. Artificial host cell lipid droplet en

SUBMITTER: Hamid PH 

PROVIDER: S-EPMC4579583 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature