Introduction and evolution of dengue virus type 2 in Pakistan: a phylogeographic analysis.

ABSTRACT:

Background

Pattern of Dengue periodic epidemics through the years along with sporadic cases of Dengue hemorrhagic fever followed by a severe 2011 epidemic of Dengue fever in Pakistan make Pakistan a Dengue endemic country. To study the entry and evolution of dengue virus serotype 2 (DENV-2) in Pakistan, we sequenced three full length genomes and 24 complete envelope sequences of DENV-2 from the years 2010, 2011 and 2013 collected from Punjab province of Pakistan.

Methods

Phylogenetic and Bayesian phylogeographic analyses was applied to three full genome sequences as well as 24 envelope sequences to study the spatiotemporal dynamics of DENV-2 in Pakistan.

Results

Most of the DENV-2 viruses from the years 2008 to 2013 formed a monophyletic Pakistani clade in IVb subline

SUBMITTER: Akram M 

PROVIDER: S-EPMC4579586 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature