Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study.

ABSTRACT:

Objective

To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment.

Design

National prospective cohort study.

Setting

15 medical centres in different regions of Taiwan, from July 2009 to August 2014.

Participants

2926 people who had an indication for allopurinol treatment but had not taken allopurinol previously. Participants were excluded if they had undergone a bone marrow transplant, were not of Han Chinese descent, and had a history of allopurinol induced hypersensitivity. DNA purified from 2910 participants' peripheral blood was used to assess the presence of HLA-B*58:01.

Main outcome measures

Incidence of allopurin

SUBMITTER: Ko TM 

PROVIDER: S-EPMC4579807 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature