Do personality traits moderate the manifestation of type 2 diabetes genetic risk?

ABSTRACT:

Objective

To test whether personality traits moderate type 2 diabetes (T2D) genetic risk.

Methods

Using a large community-dwelling sample (n=837, Mage=69.59±0.85years, 49% males) we fitted a series of linear regression models predicting glycated haemoglobin (HbA1c) from T2D polygenic risk - aggregation of small individual effects of a large number of single nucleotide polymorphisms (SNPs) - and five personality traits. We tested the main effects of personality traits and their interactions with T2D polygenic risk score, controlling for age and sex. The models in the final set were adjusted for cognitive ability, highest educational qualification, and occupational class.

Results

Lower levels of openness were associated with heightened levels of HbA1c (β=-0.014, p=.032)

SUBMITTER: Cukic I 

PROVIDER: S-EPMC4579920 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature