Systems-level organization of yeast methylotrophic lifestyle.

ABSTRACT:

Background

Some yeasts have evolved a methylotrophic lifestyle enabling them to utilize the single carbon compound methanol as a carbon and energy source. Among them, Pichia pastoris (syn. Komagataella sp.) is frequently used for the production of heterologous proteins and also serves as a model organism for organelle research. Our current knowledge of methylotrophic lifestyle mainly derives from sophisticated biochemical studies which identified many key methanol utilization enzymes such as alcohol oxidase and dihydroxyacetone synthase and their localization to the peroxisomes. C1 assimilation is supposed to involve the pentose phosphate pathway, but details of these reactions are not known to date.

Results

In this work we analyzed the regulation patterns of 5,354 genes, 57

SUBMITTER: Rußmayer H 

PROVIDER: S-EPMC4580311 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature