Case–control study of Epstein–Barr virus and Helicobacter pylori serology in Latin American patients with gastric disease.

ABSTRACT:

Background

Chronic tissue damage induced by Helicobacter pylori (HP)-driven inflammation is considered the main risk of gastric carcinoma (GC). Epstein–Barr virus (EBV) infection has also been associated with GC. In this study, we aim to address the role of EBV in inflammatory GC precursor lesions and its added risk to HP infection.

Methods

Antibodies against EBV, HP and the bacterial virulence factor CagA were measured in sera from 525 Mexican and Paraguayan patients with gastric disease. Gastric samples were characterised according to the updated Sydney classification and associations were estimated between antibody responses and severity of both tissue damage and inflammation.

Results

We found significant associations (odd ratios and trends) between EBV and HP copo

SUBMITTER: Cardenas-Mondragon MG 

PROVIDER: S-EPMC4580389 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature