Comparative outcomes of β-lactam antibiotics in outpatient parenteral antibiotic therapy: treatment success, readmissions and antibiotic switches.

ABSTRACT:

Objectives

β-Lactam antibiotics are commonly used in outpatient parenteral antimicrobial therapy (OPAT), but data regarding outcomes of long-term therapy are limited. The purpose of this study was to compare treatment success, readmission and antibiotic switch rates in patients treated with β-lactam antibiotics as OPAT.

Methods

We carried out a retrospective review of all patients, discharged from Tufts Medical Center with cefazolin, ceftriaxone, ertapenem or oxacillin, between January 2009 and June 2013. A competing risks analysis was used to compare the cumulative incidence of first occurrence of treatment success, antibiotic switch and 30 day readmission for each drug.

Results

Four hundred patients were identified (cefazolin n = 38, ceftriaxone n = 104, ertapenem n

SUBMITTER: Lee B 

PROVIDER: S-EPMC4580536 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature