Comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is the fifth most common cause of cancer deaths in women in the United States. Numerous gene signatures of patient prognosis have been proposed, but diverse data and methods make these difficult to compare or use in a clinically meaningful way. We sought to identify successful published prognostic gene signatures through systematic validation using public data.

Methods

A systematic review identified 14 prognostic models for late-stage ovarian cancer. For each, we evaluated its 1) reimplementation as described by the original study, 2) performance for prognosis of overall survival in independent data, and 3) performance compared with random gene signatures. We compared and ranked models by validation in 10 published datasets comprising 1251 primarily

SUBMITTER: Waldron L 

PROVIDER: S-EPMC4580554 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature