Type 1 diabetes is associated with an increased risk of fracture across the life span: a population-based cohort study using The Health Improvement Network (THIN).

ABSTRACT:

Objective

This study was conducted to determine if type 1 diabetes is associated with an increased risk of fracture across the life span.

Research design and methods

This population-based cohort study used data from The Health Improvement Network (THIN) in the U.K. (data from 1994 to 2012), in which 30,394 participants aged 0-89 years with type 1 diabetes were compared with 303,872 randomly selected age-, sex-, and practice-matched participants without diabetes. Cox regression analysis was used to determine hazard ratios (HRs) for incident fracture in participants with type 1 diabetes.

Results

A total of 334,266 participants, median age 34 years, were monitored for 1.9 million person-years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1

SUBMITTER: Weber DR 

PROVIDER: S-EPMC4580610 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature