Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.

ABSTRACT: Protein phosphorylation and de-phosphorylation events are crucial in deciding the fate of cells. They regulate cellular growth, differentiation and cell death, and kinases are the key players of these events. The members of ser/thr kinases and tyrosine kinases form the majority of protein kinase family, exerting their regulatory mechanism in almost all cells. In testis, they impact signal transduction events, regulate all stages of sperm development from mitosis through fertilization. Understanding the function of these kinases at the structural level and studying their interactions with inhibitors can help in understanding the machinery of spermatogenesis. In view of this, we have reviewed some of the prominent kinases that are known to play a role in spermatogenesis. A better understandi

SUBMITTER: Jenardhanan P 

PROVIDER: S-EPMC4581050 | biostudies-literature | 2014 May-Aug

REPOSITORIES: biostudies-literature