Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives.

ABSTRACT: In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents.

SUBMITTER: Wang D 

PROVIDER: S-EPMC4581214 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature