An In silico Chimeric Vaccine Targeting Breast Cancer Containing Inherent Adjuvant.

ABSTRACT:

Background

Today, Lack of efficient therapeutic strategy for breast cancer (the most common cause of death in women) is one of the momentous problematic topics for all health care committees. Designing new specific vaccine, based on antigens located on the surface of cancer cells can be useful. Over expression of ROR1, lacked of HER2/neu, and hormone receptors on cell surface in the breast cancer, introduce this protein as an appropriate candidate for designing cancer vaccine.

Objectives

We hypothesized the extracellular domain of receptor tyrosine kinase like orphan receptor 1 (ROR-1) along with a super antigen such as staphylococcal enterotoxin B could be a potent vaccine for drug resistant breast cancer.

Materials and methods

Here, we assessed the findings of bioin

SUBMITTER: Imani Fooladi AA 

PROVIDER: S-EPMC4581362 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature