Clinical features of IgA nephropathy with serum ANCA positivity: a retrospective case-control study.

ABSTRACT:

Background

The coexistence of IgA nephropathy (IgAN) and antineutrophil cytoplasmic autoantibodies (ANCAs) is relatively rare. Only a few studies have reported the features of these patients.

Methods

We studied the clinical and histological features of 20 ANCA-positive IgAN patients. They were compared with ANCA-negative IgAN patients (n = 40) and ANCA-associated systemic vasculitis (AASV) patients (n = 40) with a randomly selected and matched proportion of crescentic glomeruli. Furthermore, 9 ANCA-positive crescentic IgAN patients out of the 20 cases were compared with two control groups with crescentic nephritis.

Results

ANCA-positive IgAN patients showed older age, lower haemoglobin and higher inflammatory indicator levels at baseline, and a higher percentage of ge

SUBMITTER: Yang YZ 

PROVIDER: S-EPMC4581394 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature